Peer-reviewed Articles (Original papers and Reviews)

Peer-reviewed articles (original papers + reviews) are listed in order of publication date and color-coded by fields.

"Food Chemistry, Science and Technology" is blue.

"Inflammation, Oxidative Stress and Toxicology" is red.

"Plant Physiology and Biochemistry" is green.

"Cell Biology and Biomaterials" is pink.,

"Synthetic Chemistry for Tumor Promoters" is gray.

The papers I played a major role are in bold.

"The corresponding author" is indicated by ca, and "Equally contributed" is indicated by asterisk.

The numbers of the review articles are prefixed with R.

※査読付論文（原著論文＋総説）を掲載日時順にならべ、分野別に色分けしています。

食品科学＆食品機能系は青、炎症＆酸化ストレス＆毒性学系は赤、植物生理系は緑、

細胞生物学＆生物材料系はピンク、発がんプロモーター系は灰

※自分が主要な役割を果たした論文を太字にしています。

Corresponding authorにはca、Equally contributedには*を付記しています。

総説の番号の接頭にはRを付しています。

Original Articles & Review Articles

2025

255) TGG1 and TGG2 mutations impair allyl isothiocyanate-mediated stomatal closure in Arabidopsis thaliana.

Oumaima, K., Hossain, M.S., Ye, W., Okuma, E., Issak, M., Islam, M.Ma., Uraji, M., Nakamura, Y., Mori, I.C., Munemasa, M., Murata, Y.

Protoplasma, in press (2025).

254) Reactive carbonyl species function downstream of reactive oxygen species in chitosan-induced stomatal closure.

Jahan, I., Islam, M.Mo., Nakamura, T., Nakamura, Y., Munemasa, S., Mano, J., Murata, Y.

Physiol. Plant., in press (2025).

253) Polyphenol oxidase mediated (-)-epigallocatechin gallate stabilized protein in body wall of Apostichopus japonicus: characteristics and structure.

Guo, Y., Ming, Y., Dong, X., Nakamura, Y., Dong, X., Qi, H.

Food Chem., 470, 142710 (2025).

252) Resveratrol, a food-derived polyphenol, promotes melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways.

Okamoto, S., Kakimaru, S., Koreishi, M., Sakamoto, M., Nakamura, Y., Ando, H., Tsujino, Y., Satoh, A.

J. Funct. Foods, 125, 106672 (2025).

251) Advanced characterization of fish skin gelatin-proanthocyanidins covalent and non-covalent composite emulsions for benzyl isothiocyanate delivery.

Shen, Y., Lin, S., Song, L., Sun, P., Nakamura, Y., Tang, Y.

Int. J. Biol. Macromol., 290, 139071 (2025).

250) Mechanism of inhibition of melanoma by fucoxanthin simulated in vitro digestion products in cell models constructed using human malignant melanoma cells (A375) and keratinocytes (HaCaT).

Lu, Y., Wang, Y., Yao, T., Dong, X., Liu, Y., Nakamura, Y., Qi, H.

Food Chem., 462, 141003 (2025).

2024

249) GUARD CELL HYDROGEN PEROXIDE-RESISTANT1 functions upstream of reactive carbonyl species production in Arabidopsis guard-cell abscisic acid signaling.

Shaiek, O., Yin, H., Uesako, N., Islam, M.Mo., Rhaman. M.S., Nakamura. T., Nakamura, Y., Munemasa, S., Mano, J., Murata, Y.

Biosci. Biotechnol. Biochem., 88(12), 1403-1410 (2024).

248) Outward-rectifying potassium channels GORK and SKOR function in regulation of root growth under salt stress in Arabidopsis thaliana.

Hiya, H.J., Nakashima, Y., Takeuchi, A., Nakamura, T., Nakamura, Y., Murata, Y., Munemasa, S.

J. Plant Physiol., 302, 154322 (2024).

247) Whey protein and flaxseed gum co-encapsulated fucoxanthin promoted tumor cells apoptosis based on MAPK-PI3K/Akt regulation on Huh-7 cell xenografted nude mice.

Wang, C., Huang, X., Sun, K., Li, X., Feng, D., Nakamura, Y., Qi, H.

Int. J. Biol. Macromol., 278, 134838 (2024).

246) Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.

Xu, Y., Sawamoto, T., Sun, R., Ishikura, A., Munemasa, S., Murata, M., Satoh, A., Matsumoto, A., Nakamura, T., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 88(10), 1199-1202 (2024).

245) Quercetin attenuates acetaldehyde-induced cytotoxicity via the heme oxygenase-1-dependent antioxidant mechanism in hepatocytes.

Li, K., Kidawara, M., Chen, Q., Munemasa, S., Murata, M., Nakamura, T., Nakamura, Y.(ca)

Int. J. Mol. Sci., 25(16), 9038 (2024).

244) Polyphenol oxidase mediates (-)-epigallocatechin gallate to inhibit endogenous cathepsin activity in Apostichopus japonicus.

Guo, Y., Yu, M., Sun, K., Dong, X., Nakamura, Y., Dong, X., Qi, H.

Food Chem., 449, 139166 (2024).

243) The metabolite of γ-tocopherol, 2,7,8-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman, exerts intracellular antioxidant activity via up-regulation of heme oxygenase-1 in hepatocytes.

Aoyama, S., Nishio, T., Moriya, D., Munemasa, S., Murata, Y., Nakamura, Y., Nakamura, T.

Nutraceuticals, 4(3), 409-416 (2024).

242) Negative regulation of chitosan-induced stomatal closure by glutathione in Arabidopsis thaliana.

Jahan, I., Munemasa, S., Nakamura, T., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 88(8), 918-922 (2024).

241) Unlocking stability and efficiency in benzyl isothiocyanate-loaded emulsions: Unveiling synergistic interactions of fish skin gelatin and pectin.

Liu W., Lin S., Song L., Wang S., Nakamura Y., Tang Y.

Food Biosci., 58, 103788 (2024).

240) Enhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism.

Mitsuzane, R., Okubo, R., Nishikawa, M., Ikushiro, S., Munemasa, S., Murata, Y., Nakamura, Y., Nakamura, T.

Free Radic. Res., 58(2), 88-97 (2024).

239) Aromatic oil from lavender as an atopic dermatitis suppressant.

Sato, H., Kato, K., Koreishi, M., Nakamura, Y., Tsujino, Y., Satoh, A.

PLOS ONE, 19(1), e0296408 (2024).

2023

238) The effect of exogenous dihydroxyacetone and methylglyoxal on growth, anthocyanin accumulation, and the glyoxalase system in Arabidopsis.

Zhao, M., Nakamura, T., Nakamura, Y., Munemasa, S., Mori, I.C. Murata, Y

Biosci. Biotechnol. Biochem., 87(11), 1323-1331 (2023).

237) Detection of simulated in vitro digestion products of fucoxanthin and their photodamage alleviation effect in retinal Müller cells induced by ultraviolet B irradiation: A proteomics analysis.

Shi, Y., Wang, Y., Zou, H., Zhao, B., Zhu, T., Nakamura, Y., Qi, H.

J. Agric. Food Chem., 71(40), 14626-14637 (2023).

R15) Effects of domestic cooking methods on physicochemical properties, bioactive compounds and antioxidant activities of vegetables: A mini-review.

Jiang, S., Yu, M., Jiang, P., Nakamura, Y., Qi, H.

Food Rev. Int., 39(9), 7004-7018 (2023).

236) Characterization of zinc-chelating peptides derived from scallop (Patinopecten yessoensis) mantle and their intestinal transport in everted rat sacs.

Liu, X., Sun, J., Li, Y., Yu, X., Yin, F., Li, D., Jiang, P., Nakamura, Y., Zhou, D.

Int. J. Food Sci. Technol., 58(5), 2236-2246 (2023).

R14) Aldehyde dehydrogenases as potential targets for ethanol-related diseases.

Xu, Y., Nakamura, T., Nakamura, Y.(ca)

J. Environ. Sci. Sustain. Soc., 12(Suppl., MR) 9-12 (2023).

R13) Molecular Mechanisms for Polyphenol Functionality: How do polyphenols exert their functionality?

Nakamura, Y.(ca)

J. Integr. Stud. Diet. Habits, 33(4), 165-169 (2023).

ポリフェノールの機能性の分子メカニズム〜ポリフェノールはどのようにして機能性を発揮するのか〜

中村宜督

日本食生活学会誌, 33(4), 165-169 (2023).

235) Construction of benzyl isothiocyanate-loaded fish skin gelatin-luteolin compound emulsion delivery system, and its digestion and absorption characteristics.

Liu, Z., Lin, S., Liu, W., Nakamura, Y., Tang, Y.

J. Sci. Food Agric., 103(4), 1864-1873 (2023).

234) Polyphenol extracts from Ascophyllum nodosum protected sea cucumber (Apostichopus japonicas) body wall against thermal degradation during tenderization.

Ming, Y., Wang, Y., Xie, Y., Dong, X., Nakamura, Y., Chen, X., Qi, H.

Food Res. Int., 164, 112419 (2023).

233) Characterization of oyster water-soluble protein-EGCG conjugate and its antioxidant effects on linoleic acid in emulsion system.

Li, Y., Liu, X., Yin, Y., Li, D., Jiang, P., Song, L., Nakamura, Y., Zhou, D.

Food Biosci., 51, 102215 (2023).

232) Cycloartenyl ferulate is the predominant compound in brown rice conferring cytoprotective potential against oxidative stress-induced cytotoxicity.

Wu, Ho., Nakamura, T., Guo, Y., Matsumoto, R., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

Int. J. Mol. Sci., 24(1), 822 (2023).

Selected as the Top view papers of IJMS in 2023.

2022

231) The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress.

Li, K., Wu, Ho., Kidawara, M., Lin, Y., Satoh, A., Zhang, G., Munemasa, S., Murata, Y., Nakamura, T., Nakamura, Y.(ca)

Free Radic. Res., 56(9-10), 607-616 (2022).

230) Benzyl isothiocyanate and its metabolites inhibit cell proliferation through protein modification in mouse preosteoclast RAW264.7 cells.

Nakamura, T., Tsutsui, C., Okuda, Y. Abe-Kanoh, A., Okazawa, S., Munemasa, S., Murata, Y., Kato, Y., Nakamura, Y.(ca)

J. Biochem. Mol. Toxicol., 36(11), e23184 (2022).

229) Phlorotannin extracts from Ascophyllum nodosum inhibited proteases activities and structural changes from Apostichopus japonicus.

Ming, Y., Wang, Y., Xie, Y., Sun, C., Dong, X., Nakamura, Y., Chen, X, Dong, X., Qi, H.

ACS Food Sci. Technol., 2(10), 1586-1596 (2022).

228) Extracellular malate induces stomatal closure via direct activation of guard-cell anion channel SLAC1 and stimulation of Ca²⁺ signaling.

Mimata, Y., Munemasa, S., Nakamura, T., Nakamura, Y., Murata, Y.

New Phytol., 236(3), 852-863 (2022).

227) Influence of fish skin gelatin-sodium alginate complex stabilized emulsion on benzyl isothiocyanate stability and digestibility in vitro and in vivo.

Zhang, X., Liu, Z., Wang, A., Zhang, S., Nakamura, Y., Lin, S., Tang, Y.

J. Sci. Food Agric., 102(13), 5680-5689 (2022).

226) Negative regulation of salicylic acid-induced stomatal closure by glutathione in Arabidopsis thaliana.

Akter, F., Munemasa, S., Nakamura, T., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 86(10), 1378-1382 (2022).

225) Malate induces stomatal closure via a receptor-like kinase GHR1- and reactive oxygen species-dependent pathway in Arabidopsis thaliana.

Mimata, Y., Munemasa, S., Akter, F., Jahan, I., Nakamura, T., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 86(10), 1362-1367 (2022).

224) Immune state conversion of the mesenteric lymph node in a mouse breast cancer model.

Shigehiro, T., Ueno, M., Kijihira, M., Takahashi, R., Umemura, C., Taha, E.A., Kurosaka, C., Asayama, M., Murakami, H., Satoh, A., Nakamura, Y., Futami, J., Masuda, J.

Int. J. Mol. Sci., 23(19), 11035 (2022).

223) Characterization of a synthetic zinc-chelating peptide from sea cucumber (Stichopus japonicus) and its gastrointestinal digestion and absorption in vitro.

Wang, Z., Sun, J., Ma, X., Liu, X., Yin, F., Li, D., Nakamura, Y., Yu, C., Zhou, D.

J. Sci. Food Agric., 102(11), 4542-4550 (2022).

222) Evaluation of sensory properties, physical characteristics and antioxidant activity of superheated steam-treated brown rice.

Nishimoto, Y., Yano, A., Wu, Ho., Nishizawa, M., Nakamura, T., Fujita, A., Nakamura, Y.

J. Jpn. Soc. Taste Technol., 21(1), 20-26 (2022).

過熱水蒸気処理玄米の食味、物性および抗酸化活性の評価.

西本有紀, 矢野愛奈, Wu Hongyan, 西澤正人, 中村俊之, 藤田明子, 中村宜督.

美味技術学会誌, 21(1), 20-26 (2022).

221) Modulating effects of oral administration of Lycii fructus extracts on UVB-induced skin erythema: A randomized, placebo-controlled study.

Tsunenaga, M., Xu, W., Myojin, T., Nakamura, T., Kon, T., Nakamura, Y., Ueda, O.

Biomed. Rep., 17(1) 62 (2022).

220) Antioxidative effect of Chlorella pyrenoidosa protein hydrolysates and their application in krill oil-in-water emulsions.

Liu, Y., Qi, Y., Wang, Q., Yin, F., Zhan, H., Wang, H., Liu, B., Nakamura, Y., Wang, J.

Mar. Drugs, 20(6), 345 (2022).

219) Gastrointestinal digestion and absorption characterization in vitro of zinc-chelating hydrolysate from scallop adductor (Patinopecten yessoensis).

Sun, J., Liu, X., Wang, Z., Yin, F., Liu, H., Nakamura, Y., Yu, C., Zhou, D.

J. Sci. Food Agric., 102(8), 3277-3286 (2022).

R12) Ring fission catabolites of quercetin glycosides. (Non-peer reviewed)

Li, K., Nakamura, T., Nakamura, Y.(ca)

J. Environ. Sci. Sustain. Soc., 11(Suppl., MR) 5-8 (2022).

218) A major intestinal catabolite of quercetin glycosides, 3-hydroxyphenylacetic acid, protects the hepatocytes from the acetaldehyde-induced cytotoxicity through the enhancement of the total aldehyde dehydrogenase activity.

Liu, Y., Myojin, T., Li, K., Kurita, A., Seto, M., Motoyama, A., Liu, X., Satoh, A., Munemasa, S., Murata, Y., Nakamura, T., Nakamura, Y.(ca)

Int. J. Mol. Sci., 23(3), 1762 (2022).

217) Neither glutamate nor alanine but arginine sensitizes BY-2 cells to arsenate.

Nahar, M.N., Prodhan, M.Y., Mimata, Y., Yonezawa, A., Nakamura, T., Nakamura, Y., Munemasa, S., Murata, Y.

Biosci. Biotechnol. Biochem., 86(1), 37-46 (2022).

2021

216) White rice ethanol extract is qualitatively, but not quantitatively, equivalent to that of brown rice as an antioxidant source.

Wu, Ho., Nakamura, T., Guo, Y., Hirooka, M., Zhang, G., Munemasa, S., Murata, Y., Fujita, A., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 85(10), 2161-2168 (2021).

215) Cadmium uptake via apoplastic bypass flow in Oryza sativa L.

Mori, I.C., Arias-Barreiro, C.R., Ooi, L., Lee, N., Sobahan, M.A., Nakamura, Y., Hirai, Y., Murata, Y.

J. Plant Res., 134(5), 1139-1148 (2021).

214) Modulation of frequency and height of cytosolic calcium spikes by plasma membrane anion channels in guard cells.

Tahjib-Ul-Arif, M., Munemasa, S., Nakamura, T., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 85(9), 2003-2010 (2021).

213) Functional evaluation of the ethanol extracts from Rosmarinus officinalis L. (Rosemary).

Yamada, N., Yamasaki, T., Yamawaki, K., Nakagiri, M., Ito, H., Nakamura, Y., Nakanishi, T.

J. Hard Tissue Biol., 30(3), 291-296 (2021).

212) A multidrug resistance-associated protein inhibitor is a potential enhancer of the benzyl isothiocyanate-induced apoptosis induction in human colorectal cancer cells.

Yang, Q., Nakamura, T., Seto, M., Miyagawa, M., Xu, W., Zhu, B., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

J. Biochem. Mol. Toxicol., 35(7), e22791 (2021).

211) Luteolin suppresses 5-hydroxytryptamine elevation in stimulated RBL-2H3 cells and experimental colitis mice.

Suga, N., Murakami, A., Arimitsu, H., Nakamura, T., Nakamura, Y., Kato, Y.

J. Clin. Biochem. Nutr., 69(1) 20-27 (2021).

R11) Predominant rice phytochemicals and their disease-preventive effects. (Non-peer reviewed)

Wu, Ho., Nakamura, T., Nakamura, Y.(ca)

J. Environ. Sci. Sustain. Soc., 10(Suppl., MR) 1-4 (2021).

2020

210) Stomatal response to isothiocyanates in Arabidopsis thaliana.

Afrin, S., Okuma, E., Tahjib-Ul-Arif, M., Jahan, M.S., Nakamura, T., Nakamura, Y., Munemasa, S., Murata, Y.

J. Exp. Bot., 71(22), 6921-6931 (2020).

R10) Fucoxanthin activities motivate its nanoencapsulation for food or nutraceutical application: a review.

Wang, C., Chen, X., Nakamura, Y., Yu, C., Qi, H.

Food Funct., 11(11), 9338-9358 (2020).

209) Exogenous proline enhances antioxidant enzyme activities but does not mitigate growth inhibition by selenate stress in tobacco BY-2 cells.

Khatun, M., Matsushima, D., Rhaman, M.S., Okuma, E., Nakamura, T., Nakamura, Y., Munemasa, S., Murata, Y.

Biosci. Biotechnol. Biochem., 84(11), 2281-2292 (2020).

208) Synthesis and characterization of conductive flexible cellulose carbon nanohorn sheets for human tissue applications.

Selvam, K.P., Nagahata, T., Kato, K., Koreishi, M., Nakamura, T., Nakamura, Y., Nishikawa, T. Satoh, A., Hayashi, Y.

Biomater. Res., 24, 18 (2020).

207) Reactive carbonyl species mediate methyl jasmonate-induced stomatal closure.

Islam, M.Mo., Ye, W., Akter, F., Rhaman, M.S., Matsushima, D., Munemasa, S., Okuma, E., Nakamura, Y., Biswas, M.S., Mano, J., Murata, Y.

Plant Cell Physiol., 61(10), 1788-1797 (2020).

R9) Inhibition of drug resistance mechanisms improves the benzyl isothiocyanate-induced antiproliferation in human colorectal cancer cells.

Liu, X., Yang, Q., Nakamura, Y.(ca)

Curr. Pharmacol. Rep., 6(5), 306-314 (2020).

206) Interaction of intracellular hydrogen peroxide accumulation with nitric oxide production in abscisic acid signaling in guard cells.

Jannat, R., Senba, T., Muroyama, D., Uraji, M., Hossain, M.A., Islam, M.Mu., Nakamura, Y., Munemasa, S., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 84(7), 1418-1426 (2020).

205) Inhibition of light-induced stomatal opening by allyl isothiocyanate does not require guard cell cytosolic Ca²⁺ signaling.

Ye, W., Ando, E., Rhaman, M.S., Tahjib-Ul-Arif, M., Okuma, E., Nakamura, Y., Kinoshita, T., Murata, Y.

J. Exp. Bot., 71(10), 2922-2932 (2020).

204) Myrosinases, TGG1 and TGG2, redundantly function in reactive carbonyl species signaling in Arabidopsis guard cells.

Rhaman, M.S., Nakamura, T., Nakamura, Y., Munemasa, S., Murata, Y.

Plant Cell Physiol., 61(5), 967-977 (2020).

203) Salicylic acid receptor NPR1 is involved in guard cell chitosan signaling.

Prodhan, M.Y., Issak, M., Munemasa, S., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 84(5), 963-969 (2020).

2019

202) Characterization of benzyl isothiocyanate extracted from mashed green papaya by distillation.

Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Food Chem., 299, 125118 (2019).

201) Isolation and identification of zinc-chelating peptides from sea cucumber (Stichopus japonicus) protein hydrolysate.

Liu, X., Wang, Z., Zhang, J., Song, L., Li, D., Wu, Z., Zhu, B., Nakamura, Y., Shahidi, F., Yu, C., Zhou, D.

J. Sci. Food Agric., 99(14), 6400-6407 (2019).

200) Dynamics of the cellular metabolism of leptosperin found in manuka honey.

Kato, Y., Kawai, M., Kawai, S., Okano, Y., Rokkaku, N., Ishisaka, A., Murota, K., Nakamura, T., Nakamura, Y., Ikushiro, S.

J. Agric. Food Chem., 67(39), 10853-10862 (2019).

199) Ethylene inhibits methyl jasmonate-induced stomatal closure by modulating guard cell slow-type anion channel activity via the OPEN STOMATA 1/SnRK2.6 kinase-independent pathway in Arabidopsis.

Munemasa, S., Hirao, Y., Tanami, K., Mimata, Y., Nakamura, Y., Murata, Y.

Plant Cell Physiol., 60(10), 2263-2271 (2019).

198) The Golgin protein giantin regulates interconnections between Golgi stacks.

Satoh, A., Hayashi-Nishino, M., Shakuno, T., Masuda, J., Koreishi, M., Murakami, R., Nakamura, Y., Nakamura, T., Abe-Kanoh, N., Honjo, Y., Malsam, J., Yu, S., Nishino, K.

Front. Cell Dev. Biol., 7, 160 (2019).

197) Zinc-chelating mechanism of sea cucumber (Stichopus japonicus)-derived synthetic peptides.

Liu, X., Wang, Z., Yin, F., Liu, Y., Qin, N., Nakamura, Y., Shahidi, F., Yu, C., Zhou, D. Zhu, B.

Mar. Drugs, 17(8), E438 (2019).

196) Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12.

Abe-Kanoh, N., Kunisue, N., Myojin, T., Chino, A., Munemasa, S., Murata, Y., Satoh, A., Moriya, H., Nakamura, Y.(ca)

Sci. Rep., 9(1), 8866 (2019).

195) Reactive carbonyl species function as signal mediators downstream of H₂O₂ production and regulate [Ca²⁺]_cyt elevation in ABA signal pathway in Arabidopsis guard cells.

Islam, M.Mo., Ye, W., Matsushima, D., Rhaman, M.S., Munemasa, S., Okuma, E., Nakamura, Y., Biswas, M.S., Mano, J., Murata, Y.

Plant Cell Physiol., 60(5), 1146-1159 (2019).

194) Covalent modification of phosphatidylethanolamine by benzyl isothiocyanate and the resultant generation of ethanolamine adduct as its metabolite.

Nakamura, T., Hirakawa, M., Nakamura, Y., Ishisaka, A., Kitamoto, N., Murakami, A., Kato, Y.

Chem. Res. Toxicol., 32(4), 638-644 (2019).

2018

193) Oxidative stress involved in textural changes of sea cucumber Stichopus japonicus body wall during low-temperature treatment.

Dong, X., Qi, H., Feng, D., He, B., Nakamura, Y., Yu, C., Zhu, B.

Int. J. Food Prop., 21(1), 2646-2659 (2018).

192) Methyl-β-cyclodextrin potentiates the BITC-induced anticancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells.

Yang, Q., Miyagawa, M., Liu, X., Zhu, B., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 82(12), 2158-2167 (2018).

191) Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation.

Liang, Y., Sasaki, I., Takeda, Y., Zhu, B., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 82(12), 2130-2139 (2018).

190) Phenethyl isothiocyanate activates leptin signaling and decreases food intake.

Yagi, M., Nakatsuji, Y., Maeda, A., Ota, H., Kamikubo, R., Miyoshi, N., Nakamura, Y., Akagawa, M.

PLOS ONE, 13(11), e0206748 (2018).

189) Lycii fructus extract ameliorates hydrogen peroxide-induced cytotoxicity through indirect antioxidant action.

Xu, W., Saiki, S., Myojin, T., Liu, Y., Zhu, B., Murata, Y., Ashida, H., Tsunenaga, M., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 82(10), 1812-1820 (2018).

188) Guard cell salicylic acid signaling is integrated into abscisic acid signaling via the Ca²⁺/CPK-dependent pathway.

Prodhan, M.Y., Munemasa, S., Nahar, M.N., Nakamura, Y., Murata, Y.

Plant Physiol., 178(1), 441-450 (2018).

187) Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells.

Tang, Y., Naito, S., Abe-Kanoh, N., Ogawa, S., Yamaguchi, S., Zhu, B., Murata, Y., Nakamura, Y.(ca)

J. Biochem. Mol. Toxicol., 32(6), e22054 (2018).

186) Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats.

Nakamura, T., Kinjo, C., Nakamura, Y., Kato, Y., Nishikawa, M., Hamada, M., Nakajima, N., Ikushiro, S., Murota, K.

Arch. Biochem. Biophys., 645, 126-136 (2018).

R8) Flavonoid metabolism: the interaction of metabolites and gut microbiota.

Murota, K.*, Nakamura, Y.*, Uehara, M.

Biosci. Biotechnol. Biochem., 82(4), 600-610 (2018).

received the 2019 BBB Most-Cited Review Award！

> 400 citations (Google Scholar)

R7) Physiological relevance of covalent protein modification by dietary isothiocyanates.

Nakamura, T., Abe-Kanoh, N., Nakamura, Y.(ca)

J. Clin. Biochem. Nutr., 62(1), 11-19 (2018).

2017

185) Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.

Okuda, Y., Kushida, M, Kikumoto, H., Nakamura, Y., Higuchi, H., Kawamura, S., Cohen, S.M., Lake, B.G., Yamada, T.

J. Toxicol. Sci., 42(6), 773-788 (2017).

184) Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells.

Liu, X., Abe-Kanoh, N., Liu, Y., Zhu, B., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 81(11), 2212-2215 (2017).

183) 3,4-Dihydroxyphenylacetic acid is a potential aldehyde dehydrogenase inducer in murine hepatoma Hepa1c1c7 cells.

Liu, Y., Kurita, A., Nakashima, S., Zhu, B., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 81(10), 1978-1983 (2017).

182) Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells.

Liu, Y., Yamanaka, M., Abe-Kanoh, N., Liu, X., Zhu, B., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Food Chem. Toxicol., 108(A), 305-313 (2017).

181) Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells.

Liu, X., Takano, C., Shimizu, T., Yokobe, S., Abe-Kanoh, N., Zhu, B., Nakamura, T., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

Biochem. Biophys. Res. Commun., 491(1), 209-216 (2017).

180) (-)-Epigallocatechin-3-gallate inhibits human angiotensin-converting enzyme activity through an autoxidation-dependent mechanism.

Liu, Z., Nakashima, S., Nakamura, T., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

J. Biochem. Mol. Toxicol., 31(9), e21932 (2017).

179) Exogenous proline enhances the sensitivity of Tobacco BY-2 cells to arsenate.

Nahar, M.N., Islam, M.Mu., Hoque, M.A., Yonezawa, A., Prodhan, M.Y., Nakamura, T., Nakamura, Y., Munemasa, S., Murata, Y.

Biosci. Biotechnol. Biochem., 81(9), 1726-1731 (2017).

178) Chitosan signaling in guard cells requires endogenous salicylic acid.

Prodhan, M.Y., Issak, M., Nakamura, T., Munemasa, S., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 81(8), 1536-1541 (2017).

177) Mode of action analysis for rat hepatocellular tumors produced by the synthetic pyrethroid momfluorothrin: evidence for activation of the constitutive androstane receptor (CAR) and mitogenicity in rat hepatocytes.

Okuda, Y., Kushida, M, Sumida, K., Nagahori, H, Nakamura, Y., Higuchi, H., Kawamura, S., Lake, B.G., Cohen, S.M., Yamada, T.

Toxicol. Sci., 158(2), 412-430 (2017).

176) MPK9 and MPK12 function in SA-Induced stomatal closure in Arabidopsis thaliana.

Khokon, M.A.R., Salam, M.A., Jammes, F., Ye, W., Hossain, M.A., Okuma, E., Nakamura, Y., Mori, I.C., Kwak, J.M., Murata, Y.

Biosci. Biotechnol. Biochem., 81(7), 1394-1400 (2017).

175) Methylglyoxal induces inhibition of growth, accumulation of anthocyanin, and activation of glyoxalase I and II in Arabidopsis thaliana.

Hoque, T.S., Uraji, M., Hoque, M.A., Nakamura, Y., Murata, Y.

J. Biochem. Mol. Toxicol., 31(7), e21901 (2017).

174) Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword.

Suga, N., Murakami, A., Nakamura, Y., Ishisaka, A., Kitamoto, N., Ito, M., Kato, Y.

Free Radic. Res., 51(5), 545-553 (2017).

2016

173) Reactive carbonyl species mediate abscisic acid signaling in guard cells.

Islam, M.Mo., Ye, W., Matsushima, D., Munemasa, S., Okuma, E., Nakamura, Y., Biswas, M.S., Mano, J., Murata, Y.

Plant Cell Physiol., 57(12), 2552-2563 (2016).

172) Galloylated catechins as potent inhibitors of angiotensin converting enzyme.

Liu, Z., Nakamura, T., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

Food Sci. Technol. Res., 22(6), 847-851 (2016).

171) 3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides.

Tang, Y., Nakashima, S., Saiki, S., Myoi, Y., Abe, N., Kuwazuru, S., Zhu, B., Ashida, H., Murata, Y., Nakamura, Y.(ca)

Food Res. Int., 89(1), 716-723 (2016).

R6) Plant polyphenols as a double-edged sword in health promotion: Lessons from the experimental models using simple phenolic acids.

Nakamura, Y.(ca)

Agri-Biosci. Monogr., 6(1), 1-57 (2016).

170) A novel tag-free probe for targeting molecules interacting with a flavonoid catabolite.

Nakashima, S., Liu, Z., Yamaguchi, Y., Saiki, S., Munemasa, S., Nakamura, T., Murata, Y., Nakamura, Y.(ca)

Biochem. Biophys. Rep., 7, 240-245 (2016).

169) Involvement of OST1 protein kinase and PYR/PYL/RCAR receptors in methyl jasmonate-induced stomatal closure in Arabidopsis guard cells.

Yin, Y., Adachi, Y., Nakamura, Y., Munemasa, S., Mori, I.C., Murata, Y.

Plant Cell Physiol., 57(8), 1779-1790 (2016).

168) Effects of sodium chloride and ascorbic acid on the formation of isothiocyanates in pickled cruciferous vegetables (Turnip, Chinese Cabbage).

Miyazawa, N., Abe, M., Kimura, M., Matsuoka, H., Tanaka, S., Morimitsu, Y., Nakamura, Y., Ayabe, S., Ozawa, Y.

J. Cook. Sci. Jpn. (in Japanese), 49(2), 138-146 (2016).

アブラナ科野菜漬物（カブ，ハクサイ）のイソチオシアネート生成に関する塩化ナトリウム（NaCl）およびアスコルビン酸の影響.

宮澤紀子, 阿部雅子, 木村典代, 松岡寛樹, 田中進, 森光康次郎, 中村宜督, 綾部園子, 小澤好夫.

日本調理科学会誌, 49(2), 138-146 (2016).

167) Apoptosis induction is involved in UVA-induced autolysis in sea cucumber Stichopus japonicas.

Qi, H., Li, N., Feng, D.D., Dong, X.F., Wen, C.R., Nakamura, Y., Zhu, B.W.

J. Photochem. Photobiol. B, 158, 130-135 (2016).

166) A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation.

Asahi, T., Wu, X., Shimoda, H., Hisaka, S., Harada, E., Kanno, T., Nakamura, Y.(ca)*, Kato, Y.*, Osawa, T.

Biosci. Biotechnol. Biochem., 80(2), 313-317 (2016).

2015

165) Specific role of taurine in the 8-brominated-2´-deoxyguanosine formation.

Asahi, T., Nakamura, Y.(ca)*, Kato, Y.*, Osawa, T.

Arch. Biochem. Biophys., 586, 45-50 (2015).

164) Allyl isothiocyanate induces stomatal closure in Vicia faba.

Sobahan, M.A., Akter, N., Okuma, E., Uraji, M., Ye, W., Mori, I.C., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 79(10), 1737-1742 (2015).

163) Two guard cell MAPKs, MPK9 and MPK12, function in methyl jasmonate-induced stomatal closure in Arabidopsis thaliana.

Khokon, M.A.R., Salam, M.A., Jammes, F., Ye, W., Hossain, M.A., Uraji, M., Nakamura, Y., Mori, I.C., Kwak, J.M., Murata, Y.

Plant Biol., 17(5), 946-952 (2015).

162) Open Stomata 1 kinase is essential for yeast elicitor-induced stomatal closure in Arabidopsis.

Ye, W., Adachi, Y., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 56(6), 1239-1248 (2015).

161) Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells.

Tang, Y., Abe, N., Yoshimoto, M., Zhu, B., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 79(1), 159-163 (2015).

160) Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in Arabidopsis thaliana.

Islam, M.Mo., Ye, W., Matsushima, D., Khokon, M.A.R., Munemasa, S., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 79(1), 59-62 (2015).

2014

159) Tea catechins inhibit cell proliferation through hydrogen peroxide-dependent and -independent pathways in human T lymphocytic leukemia Jurkat cells.

Tang, Y., Abe, N., Qi, H., Zhu, B., Murata, Y., Nakamura, Y.(ca)

Food Sci. Technol. Res., 20(6), 1245-1249 (2014).

158) Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells.

Abe, N., Hou, D.X., Munemasa, S., Murata, Y., Nakamura, Y.(ca)

Cell Death Dis., 5(11), e1534 (2014).

157) Cyclic adenosine 5'-diphosphoribose (cADPR) cyclic guanosine 3',5'-monophosphate positively function in Ca²⁺ elevation in methyl jasmonate-induced stomatal closure, cADPR is required for methyl jasmonate-induced ROS accumulation NO production in guard cells.

Hossain, M.A., Ye, W., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Biol., 16(6), 1140-1144 (2014).

156) (-)-Epigallocatechin-3-gallate ameliorates photodynamic therapy responses in an in vitro T lymphocyte model.

Qi, H., Abe, N., Zhu, B., Murata, Y., Nakamura, Y.(ca)

Phytother. Res., 28(10), 1486-1491 (2014).

155) Thiol modification by bioactivated polyphenols and its potential role in skin inflammation.

Nakamura, Y.(ca), Ishii, T., Abe, N., Murata, Y.

Biosci. Biotechnol. Biochem., 78(6), 1067-1070 (2014).

154) Ascorbic acid synergistically potentiates phloxine B-induced photocytotoxicity in human acute promyelocytic leukemia cells.

Qi, H., Wu, Q., Abe, N., Saiki, S., Zhu, B., Murata, Y., Nakamura, Y.(ca)

J. Biochem. Mol. Toxicol., 28(4), 167-173 (2014).

2013

153) Effects of emulsifiers on the photostability of lycopene.

Nishino, M.*, Sakata, M., Murata, Y., Nakamura, Y.(ca)*

Food Sci. Technol. Res., 19(6), 983-987 (2013).

152) Regulation of reactive oxygen species-mediated abscisic acid signaling in guard cells and drought tolerance by glutathione.

Munemasa, S., Muroyama, D., Nagahashi, H., Nakamura, Y., Mori, I.C., Murata, Y.

Front. Plant Sci., 4, 472 (2013).

151) Difference in abscisic acid perception mechanisms between closure induction and opening inhibition of stomata.

Yin, Y., Adachi, Y., Ye, W., Hayashi, M., Nakamura, Y., Kinoshita, T., Mori, I.C., Murata, Y.

Plant Physiol., 163(2), 600-610 (2013).

150) Calcium-dependent protein kinase, CPK6, positively functions in induction by yeast elicitor of stomatal closure and inhibition by yeast elicitor of light-induced stomatal opening in Arabidopsis.

Ye, W., Muroyama, D., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Physiol., 163(2), 591-599 (2013).

149) Catalases, CAT1 and CAT3, are not key enzymes in alleviate gamma irradiation-induced DNA damage, H₂O₂ accumulation, or lipid peroxidation in Arabidopsis thaliana.

Sultana, A., Minami, I., Matsushima, D., Issak, M., Nakamura, Y., Todoriki, S., Murata, Y.

Biosci. Biotechnol. Biochem., 77(9), 1984-1987 (2013).

148) Catalase, CAT2, is not involved in mitigation of gamma irradiation-induced H₂O₂ accumulation or lipid peroxidation in Arabidopsis thaliana.

Sultana, A., Minami, I., Matsushima, D., Issak, M., Nakamura, Y., Todoriki, S., Murata, Y.

Food Irradiat. Jpn., 48(1), 38-41 (2013).

Arabidopsis thalianaにおけるガンマ線照射誘導過酸化水素蓄積と脂質過酸化の軽減にカタラーゼCAT2は関与しない.

Sultana, A., 南育子, 松島大貴, Issak, M., 中村宜督, 等々力節子, 村田芳行.

食品照射, 48(1), 38-41 (2013).

147) Effects of γ-irradiation on larval and adult stages of Tribolium castaneum (red flour beetle).

Sultana, A., Minami, I., Ichiba, R., Issak, M., Tada, M., Nakamura, Y., Miyatake, T., Todoriki, S., Murata, Y.

Food Irradiat. Jpn., 48(1), 19-23 (2013).

Tribolium castaneumの幼虫と成虫へのガンマ線の影響.

Sultana, A., 南育子, 市場隆二, Issak, M., 多田幹郎, 中村宜督, 宮竹貴久, 等々力節子, 村田芳行.

食品照射, 48(1), 19-23 (2013).

146) Endogenous abscisic acid is involved in methyl jasmonate-induced reactive oxygen species and nitric oxide production but not in cytosolic alkalization in Arabidopsis guard cells.

Ye, W., Hossain, M.A., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

J. Plant Physiol., 170(13), 1212-1215 (2013).

145) Lower photostability of capsanthin dispersed in an aqueous solution.

Nishino, M.*, Sakata, M., Murata, Y., Nakamura, Y.(ca)*

Biosci. Biotechnol. Biochem., 77(6), 1313-1316 (2013).

144) Neither endogenous abscisic acid nor endogenous jasmonate is involved in salicylic acid-, yeast elicitor-, or chitosan-induced stomatal closure Arabidopsis thaliana.

Issak, M., Okuma, E., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 77(5), 1111-1113 (2013).

143) Glucosinolate degradation products, isothiocyanates, nitriles, and thiocyanates, induce stomatal closure accompanied by peroxidase-mediated reactive oxygen species production in Arabidopsis thaliana.

Hossain, M.S., Ye, W., Hossan, M.A., Uraji, M., Okuma, E., Nakamura, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 77(5), 977-983 (2013).

142) Two guard cell-preferential MAPKs, MPK9 and MPK12, regulate YEL signaling in Arabidopsis guard cells.

Salam, M.A., Jammes, F., Hossain, M.A., Ye, W., Nakamura, Y., Mori, I.C., Kwak, J.M., Murata, Y.

Plant Biol., 15(3), 436-442 (2013).

141) Negative regulation of methyl jasmonate-induced stomatal closure by glutathione in Arabidopsis.

Akter, N., Okuma, E., Sobahan, M.A., Uraji, M., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

J. Plant Growth Regul., 32(1), 208-215 (2013).

2012

140) Effects of depletion of glutathione on abscisic acid- and methyl jasmonate-induced stomatal closure in Arabidopsis thaliana.

Akter, N., Sobahan, M.A., Uraji, M., Ye, W., Hossain, M.A., Mori, I.C., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 76(11), 2032-2037 (2012).

139) Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.

Miyoshi, N., Yonemochi, T., Tomono, S., Fukutomi, R., Nakamura, Y., Ohshima, H.

Anal. Biochem., 429(2), 124-131 (2012).

138) MAP kinases, MPK9 and MPK12, regulate chitosan-induced stomatal closure.

Salam, M.A., Jammes, F., Hossain, M.A., Ye, W., Nakamura, Y., Mori, I.C., Kwak, J.M., Murata, Y.

Biosci. Biotechnol. Biochem., 76(9), 1785-1787 (2012).

137) Methylglyoxal inhibits seed germination and root elongation and up-regulates transcription of stress-responsive genes in ABA-dependent pathway in Arabidopsis.

Hoque, T.S., Uraji, M., Tuya, A., Nakamura, Y., Murata, Y.

Plant Biol., 14(5), 854-858 (2012).

136) Effects of exogenous proline and glycinebetaine on salt tolerance of rice cultivars.

Sobahan, M.A., Akter, N., Ohno, M., Okuma, E., Hirai, Y., Mori, I.C., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 76(8), 1568-1570 (2012).

135) Methylglyoxal inhibition of cytosolic ascorbate peroxidase from Nicotiana tabacum.

Hoque, M.A, Uraji, M., Torii, A., Banu, M.N.A, Mori, I.C., Nakamura, Y., Murata, Y.

J. Biochem. Mol. Toxicol., 26(8), 315-321 (2012).

134) Catalases negatively regulate methyl jasmonate signaling in guard cells.

Jannat, R., Uraji, M., Hossain, M.A., Islam, M.Mu., Nakamura, Y., Mori, I.C., Murata, Y.

J. Plant Physiol., 169(10), 1012-1016 (2012).

133) Methylglyoxal-induced stomatal closure accompanied by peroxidase-mediated ROS production in Arabidopsis.

Hoque, T.S., Uraji, M., Ye, W., Hossain, M.A., Nakamura, Y., Murata, Y.

J. Plant Physiol., 169(10), 979-986 (2012).

132) Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.

Qi, H., Zhu, B., Abe, N., Shin, Y., Murata, Y., Nakamura, Y.(ca)

Food Chem. Toxicol., 50(6), 1841-1847 (2012).

131) Mechanisms of the selenium tolerance of the Arabidopsis thaliana knockout mutant of sulfate transporter SULTR1;2.

Ohno, M., Uraji, M., Shimoishi, Y., Mori, I.C., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 76(5), 993-998 (2012).

130) Effect of γ irradiation on the fatty acid composition of soybean and soybean oil.

Minami, I., Nakamura, Y., Todoriki, S., Murata, Y.

Biosci. Biotechnol. Biochem., 76(5), 900-905 (2012).

129) Cooperative function of PLDδ and PLDα1 in abscisic acid-induced stomatal closure in Arabidopsis.

Uraji, M., Katagiri, T., Okuma, E., Ye, W., Hossain, M.A., Masuda, C., Miura, A., Nakamura, Y., Mori, I.C., Shinozaki, K., Murata, Y.

Plant Physiol., 159(1), 450-460 (2012).

128) Luteolin overcomes resistance to benzyl isothiocyanate-induced apoptosis in human colorectal cancer HCT-116 cells.

Sakai, R., Yokobe, S., Abe, N., Miyoshi, N., Murata, Y., Nakamura, Y.(ca)

J. Food Drug Anal., 20(Suppl.), 389-393 (2012).

127) Increased halogenated tyrosine levels are useful markers of human skin ageing, reflecting proteins denatured by past skin inflammation.

Ishitsuka, Y., Maniwa, F., Koide, C., Kato, Y., Nakamura, Y., Osawa, T., Tanioka, M., Miyachi, Y.

Clin. Exp. Dermatol., 37(3), 252-258 (2012).

126) Inhibitory effects of methylglyoxal on light-induced stomatal opening and inward K(+) channel activity in Arabidopsis.

Hoque, T.S., Okuma, E., Uraji, M., Furuichi, T., Sasaki, T., Hoque, M.A., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 76(3), 617-619 (2012).

125) α-Tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate.

Abe, N., Shimizu, T., Miyoshi, N., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 76(2), 381-383 (2012).

124) Cytotoxicity of benzyl isothiocyanate in normal renal proximal tubular cells and its modulation by glutathione.

Abe, N., Okuhira, M., Tsutsui, C., Shimoishi, Y., Murata, Y., Nakamura, Y.(ca)

J. Agric. Food Chem., 60(7), 1887-1892 (2012).

123) FIA functions as an early signal component of abscisic acid signal cascade in Vicia faba guard cells.

Sugiyama, Y., Uraji, M., Watanabe-Sugimoto, M., Okuma, E., Munemasa, S., Shimoishi, Y., Nakamura, Y., Mori, I.C., Iwai, S., Murata, Y.

J. Exp. Bot., 63(3), 1357-1365 (2012).

2011

122) Negative regulation of abscisic acid-induced stomatal closure by glutathione in Arabidopsis.

Okuma, E., Jahan, M.S., Munemasa, S., Hossain, M.A., Muroyama, D., Islam, M.Ma., Ogawa, K., Watanabe-Sugimoto, M., Nakamura, Y., Shimoishi, Y., Mori, I.C., Murata, Y.

J. Plant Physiol., 168(17), 2048-2055 (2011).

121) Allyl isothiocyanate (AITC) induces stomatal closure in Arabidopsis.

Khokon, M.A.R., Jahan, M.S., Rahman, T., Hossain, M.A., Muroyama, D., Minami, I., Munemasa, S., Mori, I.C., Nakamura, Y., Murata, Y.

Plant Cell Environ., 34(11), 1900-1906 (2011).

120) Roles of intracellular hydrogen peroxide accumulation in abscisic acid signaling in Arabidopsis guard cells.

Jannat, R., Uraji, M., Morofuji, M., Islam, M.Mu., Bloom, R.E., Nakamura, Y., McClungd, C.R., Schroeder, J.I., Mori, I.C., Murata, Y.

J. Plant Physiol., 168(16), 1919-1926 (2011).

119) K252a-sensitive protein kinases but not okadaic acid-sensitive protein phosphatases regulate methyl jasmonate-induced cytosolic Ca(2+) oscillation in guard cells of Arabidopsis thaliana.

Hossain, M.A., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

J. Plant Physiol., 168(16), 1901-1908 (2011).

118) The roles of CATALASE2 in abscisic acid signaling in Arabidopsis guard cells.

Jannat, R., Uraji, M., Morofuji, M., Hossain, M.A., Islam, M.Mu., Nakamura, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 75(10), 2034-2036 (2011).

117) Localized cysteine sulfenic acid formation by vascular endothelial growth factor: Role in endothelial cell migration and angiogenesis.

Kaplan, N., Urao, N., Furuta, E., Kim, S.J., Razvi, M., Nakamura, Y., McKinney, R.D., Poole, L.B., Fukai, T., Ushio-Fukai, M.

Free Radic. Res., 45(10), 1124-1135 (2011).

116) Histochemical quantification of glutathione contents in guard cells of Arabidopsis thaliana.

Jahan, M.S., Nakamura, Y., Murata, Y.

ScienceAsia, 37(3), 281-284 (2011).

115) Photostability of lycopene dispersed in an aqueous solution.

Nishino, M., Miuchi, T., Sakata, M., Nishida, A., Murata, Y., Nakamura, Y.

Biosci. Biotechnol. Biochem., 75(7), 1389-1391 (2011).

114) Hydrogen peroxide-dependent photocytotoxicity by phloxine B, a xanthene food colorant.

Qi, H., Takano, H., Kato, Y., Wu, Q., Ogata, C., Zhu, B., Murata, Y., Nakamura, Y.(ca)

Biochim. Biophys. Acta Gen. Sub., 1810(7), 704-712 (2011).

Corrigendum: Biochim. Biophys. Acta Gen. Sub., 1820(7), 1020 (2012).

113) (-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD box RNA helicase p68.

Tanaka, T., Ishii, T., Mizuno, D., Mori, T., Yamaji, R., Nakamura, Y., Kumazawa, S., Nakayama, T., Akagawa, M.

Free Radic. Biol. Med., 50(10), 1324-1335 (2011).

112) Involvement of endogenous abscisic acid in methyl jasmonate-induced stomatal closure in Arabidopsis.

Hossain, M.A., Okuma, E., Munemasa, S., Uraji, M., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Physiol., 156(1), 430-438 (2011).

111) Involvement of extracellular oxidative burst in salicylic acid-induced stomatal closure in Arabidopsis.

Khokon, M.A.R., Hossain, M.A., Munemasa, S., Uraji, M., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Enviromen., 34(3), 434-443 (2011).

110) The Arabidopsis calcium dependent protein kinase, CPK6, functions as a positive regulator of methyl jasmonate signaling in guard cells.

Munemasa, S., Hossain, M.A., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Physiol., 155(1), 553-561 (2011).

2010

109) The involvement of intracellular glutathione in methyl jasmonate signaling in Arabidopsis guard cells.

Akter, N., Sobahan, M.A., Hossain, M.A., Uraji, M., Nakamura, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 51(12), 2504-2506 (2010).

108) Covalent binding of tea catechins to protein thiols: Relationship between stability and electrophilic reactivity.

Mori, T., Ishii, T., Akagawa, M., Nakamura, Y., Nakayama, T.

Biosci. Biotechnol. Biochem., 51(12), 2451-2456 (2010).

107) Chitosan-induced stomatal closure accompanied by peroxidase-mediated reactive oxygen species production in Arabidopsis.

Khokon, M.A.R., Uraji, M., Munemasa, S., Okuma, E., Nakamura, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 74(11), 2313-2315 (2010).

106) Yeast elicitor-induced stomatal closure and peroxidase-mediated ROS production in Arabidopsis.

Khokon, M.A.R., Hossain, M.A., Munemasa, S., Uraji, M., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 51(11), 1915-1921 (2010).

105) The effects of methylglyoxal on glutathione S-transferase from Nicotiana tabacum.

Hoque, M.A., Uraji, M., Banu, M.N.A., Mori, I.C., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 74(10), 2124-2126 (2010).

104) Proline and glycinebetaine ameliorate NaCl stress via scavenging hydrogen peroxide and methylglyoxal but not superoxide and nitric oxide in tobacco cultured cells.

Banu, M.N.A., Hoque, M.A., Watanabe-Sugimoto, M., Islam, M.Mu., Uraji, M., Matsuoka, K., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 74(10), 2043-2049 (2010).

103) Cytosolic alkalization and cytosolic calcium oscillation in Arabidopsis guard cells response to ABA and MeJA.

Islam, M.Ma., Hossain, M.A., Jannat, R., Munemasa, S., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 51(10), 1721-1730 (2010).

102) Artificial food colorants inhibit superoxide production in differentiated HL-60 cells.

Qi, H., Kawagishi, M., Yoshimoto, M., Takano, H., Zhu, B., Shimoishi, Y., Tada, M., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 74(8), 1725-1728 (2010).

R5) Electrophiles in foods: The current status of isothiocyanates and their chemical biology.

Nakamura, Y.(ca), Miyoshi, N.

Biosci. Biotechnol. Biochem., 74(2), 242-255 (2010).

101) Roles of AtTPC1, vacuolar two pore channel 1, in Arabidopsis stomatal closure.

Islam, M.Ma., Munemasa, S., Hossain, M.A., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 51(2), 302-311 (2010).

100) A fraction of unripe kiwi fruit extract regulates adipocyte differentiation and function in 3T3-L1 cells.

Abe, D., Saito, T., Kubo, Y., Nakamura, Y., Sekiya, K.

BioFactors, 36(1), 52-59 (2010).

2009

99) Identification and characterization of sesaminol metabolites in the liver.

Mochizuki, M., Tsuchie, Y., Nakamura, Y., Osawa T.

J. Agric. Food Chem., 57(21), 10429-10434 (2009).

98) Proline and glycinebetaine confer cadmium tolerance on cultured tobacco Bright Yellow-2 cells by increasing ascorbate-glutathione cycle enzyme activities.

Islam, M.Mu., Hoque, M.A., Okuma, E., Jannat, R., Banu, M.N.A., Jahan, M.S., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 73(10), 2320-2323 (2009).

97) Catechol-type polyphenol is a potential modifier of protein sulfhydryls: Development and application of a new probe for understanding the dietary polyphenol actions.

Ishii, T., Ishikawa, M., Miyoshi, N., Yasunaga, M., Akagawa, M., Uchida, K., Nakamura, Y.(ca)

Chem. Res. Toxicol., 22(10), 1689-1698 (2009).

96) Exogenous proline and glycinebetaine increase antioxidant enzyme activities and confer tolerance to cadmium stress in cultured tobacco cells.

Islam, M.Mu., Hoque, M.A., Okuma, E. Banu, M.N.A., Shimoishi, Y., Nakamura, Y., Murata, Y.

J. Plant Physiol., 166(15), 1587-1597 (2009).

95) JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812 cells.

Wu, Ha., Qi, H., Iwasaki, D., Zhu, B., Shimoishi, Y., Murata, Y., Nakamura, Y.(ca)

Free Radic. Biol. Med., 47(7), 1028-1038 (2009).

94) Exogenous proline and glycinebetaine suppress apoplastic flow to reduce Na(+) uptake in rice seedlings.

Sobahan, M.A., Arias, C.R., Okuma, E., Shimoishi, Y., Nakamura, Y., Hirai, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 73(9), 2037-2042 (2009).

93) Myrosinases, TGG1 and TGG2 redundantly function in ABA and MeJA signaling in Arabidopsis guard cells.

Islam, M.Ma., Tani, C., Watanabe-Sugimoto, M., Uraji, M., Jahan, M.S., Masuda, C., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 50(6), 1171-1175 (2009).

92) Induction of apoptosis by β-carotene and dimethyl tetrasulfide assisted by UVA irradiation in HL-60 cells.

Zhang, G., Wu, Ha., Zhu, B., Shimoishi, Y., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 73(5), 1014-1020 (2009).

R4) Chemoprevention by Isothiocyanates: Molecular Basis of Apoptosis Induction.

Nakamura, Y.(ca)

Forum Nutr., 61, 170-181 (2009).

91) (-)-Epigallocatechin-3-gallate induces up-regulation of Th1 and Th2 cytokine genes in Jurkat T cells.

Wu, Ha., Zhu, B., Shimoishi, Y., Murata, Y., Nakamura, Y.(ca)

Arch. Biochem. Biophys., 483(1), 99-105 (2009).

90) Nitric oxide functions in both methyl jasmonate signaling and abscisic acid signaling in Arabidopsis guard cells.

Saito, N., Nakamura, Y., Mori, I.C., Murata, Y.

Plant Signal. Behav., 4(2), 119-120 (2009).

89) Proline and glycinebetaine induce antioxidant defense gene expression and suppress cell death in cultured tobacco cells under salt stress.

Banu, M.N.A., Hoque, M.A., Watanabe-Sugimoto, M., Matsuoka, K., Nakamura, Y., Shimoishi, Y., Murata, Y.

J. Plant Physiol., 166(2), 146-156 (2009).

88) Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells.

Wu, Ha., Ichikawa, S., Tani, C., Zhu, B., Tada, M., Shimoishi, Y., Murata, Y., Nakamura, Y.(ca)

Biochim. Biophys. Acta Mol. Cell Biol. Lipid, 1791(1), 8-16 (2009).

2008

87) (-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes.

Wu, Ha., Yokoyama, T., Zhu, B., Shimoishi, Y., Murata, Y., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 72(11), 3034-3037 (2008).

86) Effect of dimethyl sulfides on the induction of apoptosis in human leukemia Jurkat cells and HL-60 cells.

Zhang, G., Wu, Ha., Zhu, B., Shimoishi, Y., Nakamura, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 72(11), 2966-2972 (2008).

85) Deficient glutathione in guard cells facilitates abscisic acid-induced stomatal closure but does not affect light-induced stomatal opening.

Jahan, M.S., Ogawa, K., Nakamura, Y., Shimoishi, Y., Mori, I.C., Murata, Y.

Biosci. Biotechnol. Biochem., 72(10), 2795-2798 (2008).

84) ATP depletion alters the mode of cell death induced by benzyl isothiocyanate.

Miyoshi, N., Watanabe, E., Osawa, T., Okuhira, M., Murata, Y., Ohshima, H., Nakamura, Y.(ca)

Biochim. Biophys. Acta Mol. Basis Dis., 1782(10), 566–573 (2008).

83) Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid.

Saito, N., Munemasa, S., Nakamura, Y., Shimoishi, Y., Mori, I.C., Murata, Y.

Plant Cell Physiol., 49(9), 1396-1401 (2008).

82) Structure-dependent photodegradation of carotenoids accelerated by dimethyl tetrasulfide under UVA irradiation.

Zhang, G., Zhu, B., Nakamura, Y., Shimoishi, Y., Murata, Y.

Biosci. Biotechnol. Biochem., 72(8), 2176-2183 (2008).

R3) Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy.

Ushio-Fukai, M., Nakamura, Y.

Cancer Lett., 266(1), 37-52 (2008).

Top 25 of the most cited articles published since 2007, extracted from SciVerse Scopus.

> 800 citations (Google Scholar)

81) Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage.

Kawai, Y., Matsui, Y., Kondo, H., Morinaga, H., Uchida, K., Miyoshi, N., Nakamura, Y., Osawa, T.

Chem. Res. Toxicol., 21(7), 1407-1414 (2008).

80) Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.

Nakamura, Y., Patrushev, N., Inomata, H., Mehta, D., Kim, H.W., Urao, N., Razvi, M., Kini, V., Mahadev, K., Goldstein, B.J., McKinney, R., Fukai, T., Ushio-Fukai, M.

Circ. Res., 102(10), 1182-1191 (2008).

Erratum: Circ. Res., 113(10), e101 (2013).

79) Proline and glycinebetaine enhance antioxidant defense and methylglyoxal detoxification systems and reduce NaCl-induced damage in cultured tobacco cells.

Hoque, M.A., Banu, M.N.A., Nakamura, Y., Shimoishi, Y., Murata, Y.

J. Plant Physiol., 165(8), 813-824 (2008).

2007

78) Exogenous proline and glycinebetaine increase NaCl-induced ascorbate-glutathione cycle enzyme activities, and proline improves salt tolerance more than glycinebetaine in tobacco Bright Yellow-2 suspension-cultured cells.

Hoque, M.A., Banu, M.N.A., Okuma, E., Amako, K., Nakamura, Y., Shimoishi, Y., Murata, Y.

J. Plant Physiol., 164(11), 1457-1468. (2007).

77) Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal.

Miyoshi, N., Naniwa, K., Yamada, T., Osawa, T., Nakamura, Y.(ca)

Arch. Biochem. Biophys., 466(2), 274-282 (2007).

76) Papaya seed represents a rich source of biologically active isothiocyanate.

Nakamura, Y.(ca), Yoshimoto, M., Murata, Y., Shimoishi, Y., Asai, Y., Park, E.Y., Sato, K., Nakamura, Y.

J. Agric. Food Chem., 55(11), 4407-4413 (2007).

75) Detection of modified tyrosines as an inflammation marker in a photo-aged skin model.

Ishitsuka, Y., Maniwa, F., Koide, C., Dozaki, N., Kato, Y., Nakamura, Y., Osawa, T.,

Photochem. Photobiol., 83(3), 698-705 (2007).

74) Exogenous proline mitigates the detrimental effects of salt stress more than exogenous betaine by increasing antioxidant enzyme activities.

Hoque, M.A., Okuma, E., Banu, M.N.A., Nakamura, Y., Shimoishi, Y., Murata, Y.

J. Plant Physiol., 164(5), 553-561 (2007).

73) The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production.

Munemasa, S., Oda, K., Watanabe-Sugimoto, M., Nakamura, Y., Shimoishi, Y., Murata, Y.

Plant Physiol., 143(3), 1398-1407 (2007).

72) Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells.

Miyoshi, N., Uchida, K., Osawa, T., Nakamura, Y.(ca)

Int. J. Cancer, 120(3), 484-492 (2007).

2006

71) Expression and Ca(2+) dependency of plasma membrane K(+) channels of tobacco suspension cells adapted to salt stress.

Kasukabe, N., Watanabe-Sugimoto, M., Matsuoka, K., Okuma, E., Obi, I., Nakamura, Y., Shimoishi, Y., Murata, Y., Kakutani, T.

Plant Cell Physiol., 47(12), 1674-1677 (2006).

70) A novel labdane-type trialdehyde from Myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase.

Abe, M., Ozawa, Y., Uda, Y., Morimitsu, Y., Nakamura, Y., Osawa, T.

Biosci. Biotechnol. Biochem., 70(10), 2494-2500 (2006).

R2) Cell death induction by isothiocyanates and their underlying molecular mechanisms.

Nakamura, Y.(ca), Miyoshi, N.

BioFactors, 26(2), 123-134 (2006).

2005

69) Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction.

Kawakami, M., Harada, N., Hiratsuka, M., Kawai, K., Nakamura, Y.(ca)

Biosci. Biotechnol. Biochem., 69(12), 2439-2444 (2005).

68) A fermented grain food product extract ameliorates tumor promoter-induced skin oxidative stress.

Nakamura, Y.(ca), Osawa, T.

Food Sci. Technol. Res., 11(4), 373-375 (2005).

67) α-Tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli.

Miyoshi, N., Naniwa, K., Kumagai, T., Uchida, K., Osawa, T., Nakamura, Y.(ca)

Biochem. Biophys. Res. Commun., 334(2), 466-473 (2005).

66) Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus.

Miyake, Y., Fukumoto, S., Okada, M., Sakaida, K., Nakamura, Y., Osawa, T.

J. Agric. Food Chem., 53(1), 22-27 (2005).

2004

65) Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration.

Nakamura, Y.(ca), Miyoshi, N., Takabayashi, S., Osawa, T.

BioFactors, 21(1-4), 255-257 (2004).

64) Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes.

Miyoshi, N., Uchida, K., Osawa, T., Nakamura, Y.(ca)

BioFactors, 21(1-4), 23-26 (2004).

63) Endogenous formation of novel halogenated 2'-deoxycytidine: Hypohalous acid-mediated DNA modification at the site of inflammation.

Kawai, Y., Morinaga, H., Kondo, H., Miyoshi, N., Nakamura, Y., Uchida, K., Osawa, T.

J. Biol. Chem., 279(49), 51241-51249 (2004).

62) Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes.

Nakamura, Y.(ca), Yoshida, C., Murakami, A., Ohigashi, H., Osawa, T., Uchida, K.

FEBS Lett., 572(1-3), 245-250 (2004).

61) Antimicrobial activities of diterpene dialdehydes, constituents from Myoga (Zingiber mioga Roscoe) and their quantitative analysis.

Abe, M., Ozawa, Y., Uda, Y., Yamada, F., Morimitsu, Y., Nakamura, Y., Osawa, T.

Biosci. Biotechnol. Biochem., 68(7), 1601-1604 (2004).

60) Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.

Murakami, A., Tanaka, T., Lee, J.Y., Surh, Y.J., Kim, H.W., Kawabata, K., Nakamura, Y., Jiwajinda, S., Ohigashi, H.

Int. J. Cancer, 110(4), 481-490 (2004).

59) Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: Implication for prevention against inflammation-related carcinogenesis.

Miyoshi, N., Takabayashi, S., Osawa, T., Nakamura, Y.(ca)

Carcinogenesis, 25(4), 567-575 (2004).

58) A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: Involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation.

Miyoshi, N., Uchida, K., Osawa, T., Nakamura, Y.(ca)

Cancer Res., 64(6), 2134-2142 (2004).

57) Extract of vinegar “Kurosu” from unpolished rice inhibits the proliferation of human cancer cells.

Nanda, K., Miyoshi, N., Nakamura, Y., Shimoji, Y., Tamura, Y., Nishikawa, Y., Uenakai, K., Kohno, H., Tanaka, T.

J. Exp. Clin. Cancer Res., 23(1), 69-75 (2004).

2003

56) Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation.

Nakamura, Y.(ca), Kozuka, M., Naniwa, K., Takabayashi, S., Torikai, K., Hayashi, R., Sato, T., Ohigashi, H., Osawa, T.

Free Radic. Biol. Med., 35(9), 997-1007 (2003).

55) Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells.

Miyoshi, N., Nakamura, Y.(ca), Ueda, Y., Abe, M., Ozawa, Y., Uchida, K., Osawa, T.

Cancer Lett., 199(2), 113-119 (2003).

54) Dihydrochalcones: Evaluation as novel radical-scavenging antioxidants.

Nakamura, Y.(ca), Watanabe, S., Miyake, N., Kohno, H., Osawa, T.

J. Agric. Food Chem., 51(11), 3309-3312 (2003).

53) Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds.

Feng, Q., Kumagai, T., Nakamura, Y., Uchida, K., Osawa, T.

Mutat. Res., 537(1), 101-108 (2003).

52) Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone.

Nakamura, Y.(ca), Kumagai, T., Yoshida, C., Naito, Y., Miyamoto, M., Ohigashi, H., Osawa, T., Uchida, K.

Biochemistry, 42(14), 4300-4309 (2003).

51) Structures of (−)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (−)-epicatechin: differences between human and rat.

Natsume, M., Osakabe, M., Oyama, M., Sasaki, M., Baba, S., Nakamura, Y., Osawa, T., Terao, J.

Free Radic. Biol. Med., 34(7), 840-849 (2003).

50) A phase II detoxification enzyme inducer from lemongrass: Identification of citral and involvement of electrophilic reaction in the enzyme induction.

Nakamura, Y.(ca), Miyamoto, M., Murakami, A., Ohigashi, H., Osawa, T., Uchida, K.

Biochem. Biophys. Res. Commun., 302(3), 593-600 (2003).

2002

49) Labdane-type diterpene dialdehyde, pungent principle of myoga, Zingiber mioga Roscoe.

Abe, M., Ozawa, Y., Uda, Y., Yamada, Y., Morimitsu, Y., Nakamura, Y., Osawa, T.

Biosci. Biotechnol. Biochem., 66(12), 2698-2670 (2002).

48) Isolation and identification of DPPH radical scavenging compounds in Kurosu (Japanese unpolished rice vinegar).

Shimoji, Y., Tamura, Y., Nakamura, Y., Nanda, K., Nishidai, S., Nishikawa, Y., Ishihana, N., Uenakai, K., Ohigashi, H.

J. Agric. Food Chem., 50(22), 6501-6503 (2002).

47) Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.

Feng, Q., Kumagai, T., Nakamura, Y., Uchida, K., Osawa, T.

Xenbiotica, 32(11), 1033-1043 (2002).

46) FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid.

Murakami, A., Nakamura, Y., Koshimizu, K., Takahashi, D., Matsumoto, K., Hagihara, K., Taniguch, H., Nomura, E., Hosoda, A., Tsuno, T., Maruta, Y., Kim, H.W., Kawabata, K., Ohigashi, H.

Cancer Lett., 180(2), 121-129 (2002).

45) Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein producton, and cancer cell proliferation accompanied by apoptosis: The α,β-unsaturated carbonyl group is a prerequisite.

Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H.W., Yoshihiro, A., Nakamura, Y., Jiwajinda, S., Terao, J., Ohigashi, H.

Carcinogenesis, 23(5), 795-802 (2002).

44) Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis.

Nakamura, Y.(ca), Kawakami, M., Yoshihiro, A., Miyoshi, N., Ohigashi, H., Kawai, K., Osawa, T., Uchida, K.

J. Biol. Chem., 277(10), 8492-8499 (2002).

43) Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS-52 cells.

Kim, H.W., Murakami, A., Nakamura, Y., Ohigashi, H.

Cancer Lett., 176(1), 7-16 (2002).

42) A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.

Morimitsu, Y., Nakagawa, Y., Hayashi, H., Fujii, H., Kumagai, T., Nakamura, Y., Osawa, T., Horio, F., Itoh, K., Iida, K., Yamamoto, M., Uchida, K.

J. Biol. Chem., 277(5), 3456-3463 (2002).

41) Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant: Implication for inflammation-associated carcinogenesis.

Nakamura, Y., Feng, Q., Kumagai, T., Torikai, K., Ohigashi, H., Osawa, T., Noguchi, N., Niki, E., Uchida, K.

J. Biol. Chem., 277(4), 2687-2694 (2002).

40) Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression.

Kumagai, T., Nakamura, Y., Osawa, T., Uchida, K.

Arch. Biochem. Biophys., 397(2), 240-245 (2002).

39) Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.

Feng, Q., Torii, Y., Uchida, K., Nakamura, Y., Hara, Y., Osawa, T.

J. Agric. Food Chem., 50(1), 213-220 (2002).

2001

38) Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress.

Feng, Q., Kumagai, T., Torii, Y., Osawa, T., Nakamura, Y., Uchida, K.

Free Radic. Res., 35(6), 779-788 (2001).

37) Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney.

Nakamura, Y., Torikai, K., Ohigashi, H.

J. Agric. Food Chem., 49(11), 5674-5678 (2001).

36) A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway.

Nakamura, Y., Torikai, K., Ohigashi, H.

Free Radic. Biol. Med., 30(9), 967-978 (2001).

35) The amide hydrogen of (-)-indolactam-V and benzolactamV8's plays a critical role in protein kinase C binding and tumor-promoting activities.

Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H.

Bioorg. Med. Chem. Lett., 11(5), 723-728 (2001).

34) The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.

Tanaka, M., Irie, K., Nakagawa, Y., Nakamura, Y., Ohigashi, H., Wender, P.A.

Bioorg. Med. Chem. Lett., 11(5), 719-722 (2001).

2000

33) Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.

Murakami, A., Nakamura, Y., Ohto, Y., Yano, M., Koshiba, T., Koshimizu, K., Tokuda, H., Nishino, H., Ohigashi, H.

BioFactors, 12(1-4), 187-192 (2000).

32) Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells co-cultured with interferon-γ-stimulated RAW 264.7 cells: The role of tumor necrosis factor-α.

Murakami, A., Kawabata, K., Koshiba, T., Gao, G., Nakamura, Y., Koshimizu, K., Ohigashi, H.

Cancer Res., 60(22), 6326-6331 (2000).

31) An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.

Kim, O.K., Murakami, A., Takahashi, D., Nakamura, Y., Torikai, K., Kim, H.W., Ohigashi, H.

Biosci. Biotechnol. Biochem., 64(11), 2504-2507 (2000).

30) Inhibition by (+)-persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes.

Kim, O.K., Murakami, A., Nakamura, Y., Kim, H.W., Ohigashi, H.

Biosci. Biotechnol. Biochem., 64(11), 2500-2503 (2000).

Erratum: Biosci. Biotechnol. Biochem., 74(12), 2010E2 (2010).

29) Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate.

Irie, K., Nakahara, A., Ikawa, Y., Tanaka, M., Nakagawa, Y., Nakamura, Y., Ohigashi, H., Wender, P.A.

Biosci. Biotechnol. Biochem., 64(11), 2429-2436 (2000).

28) A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: Dose- and timing-dependent enhancement and involvement of bioactivation by tyrosinase.

Nakamura, Y., Torikai, K., Ohto, Y., Murakami, A., Tanaka, T., Ohigashi, H.

Carcinogenesis, 21(10), 1899-1907 (2000).

27) Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation.

Murakami, A., Nakamura, Y., Tanaka, T., Kawabata, K., Takahashi, D., Koshimizu, K., Ohigashi, H.

Carcinogenesis, 21(10), 1843-1850 (2000).

26) Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.

Murakami, A., Nakamura, Y., Torikai, K., Tanaka, T., Koshiba, T., Koshimizu, K., Kuwahara, S., Takahashi, Y., Ogawa, K., Yano, M., Tokuda, H., Nishino, H., Mimaki, Y., Sashida, Y., Kitanaka, S., Ohigashi, H.

Cancer Res., 60(18), 5059-5066 (2000).

25) Kurosu, a traditional vinegar produced from unpolished rice, suppresses lipid peroxidation in vitro and in mouse skin.

Nishidai, S., Nakamura, Y., Torikai, K., Yamamoto, M., Ishihara, N., Mori, H., Ohigashi, H.

Biosci. Biotechnol. Biochem., 64(9), 1909-1914 (2000).

24) A glutathione S-transferase inducer from papaya: Rapid screening, identification and structure-activity relationship of isothiocyanates.

Nakamura, Y.(ca)*, Morimitsu, Y., Uzu, T., Ohigashi, H., Murakami, A., Naito, Y., Nakagawa, Y., Osawa, T., Uchida, K.*

Cancer Lett., 157(2), 193-200 (2000).

23) 4-Hydroxy-2-nonenal, the end product of lipid peroxidation, is a specific inducer of cyclooxygenase-2 gene expression.

Kumagai, T., Kawamoto, Y., Nakamura, Y., Hatayama, I., Satoh, K., Osawa, T., Uchida, K.

Biochem. Biophys. Res. Commun., 273(2), 437-441 (2000).

22) Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.

Kim, O.K., Murakami, A., Nakamura, Y., Takeda, N., Koshizumi, H., Ohigashi, H.

J. Agric. Food Chem., 48(5), 1557-1563 (2000).

21) Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes: 15-Deoxy-delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases.

Kawamoto, Y.*, Nakamura, Y.*, Naito, Y., Torii, Y., Kumagai, T., Osawa, T., Ohigashi, H., Sato, K., Imagawa, M., Uchida, K.

J. Biol. Chem., 275(15), 11291-11299 (2000).

20) Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: Correlation of enzyme induction with the formation of reactive oxygen intermediates.
Nakamura, Y.(ca)*, Ohigashi, H., Masuda, S., Murakami, A., Morimitsu, Y., Kawamoto, Y., Osawa, T., Imagawa, M., Uchida, K.*

Cancer Res., 60(2), 219-225 (2000).

R1) Search for naturally-occurring antioxidative chemopreventors on the basis of the involvement of leukocyte-derived reactive oxygen species in carcinogenesis.

Nakamura, Y., Murakami, A., Ohigashi, H.

Asian Pac. J. Cancer Prev., 1, 115-120 (2000).

1999

19) A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Nakamura, Y., Kawamoto, N., Ohto, Y., Torikai, K., Murakami, A., Ohigashi, H.

Cancer Lett., 140(1-2), 37-45 (1999).

18) Activation of stress signaling pathways by the end product of lipid peroxidation. 4-Hydroxy-2-nonenal is a potential inducer of intracellular peroxide production.

Uchida, K., Shiraishi, M., Naito, Y., Torii, Y., Nakamura, Y., Osawa, T.

J. Biol. Chem., 274(4), 2234-2242 (1999).

1998

17) Isolation and identification of acetylenic spiroketal enol ethers from Artemisia lactiflora as inhibitors of superoxide generation induced by a tumor promoter in differentiated HL-60 cells.

Nakamura, Y., Ohto, Y., Murakami, A., Jiwajinda, S., Ohigashi, H.

J. Agric. Food Chem., 46(12), 5031-5036 (1998).

16) Superoxide scavenging activity of rosmarinic acid from Perilla frutescens Britton var. acuta f. viridis.

Nakamura, Y., Ohto, Y., Murakami, A., Ohigashi, H.

J. Agric. Food Chem., 46(11), 4545-4550 (1998).

15) Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
Nakamura, Y., Murakami, A., Ohto, Y., Torikai, K., Tanaka, T., Ohigashi, H.

Cancer Res., 58(21), 4832-4839 (1998).

14) Synthsis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V.

Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H., Hayashi, H.

Biosci. Biotechnol. Biochem., 62(8), 1568-1573 (1998).

13) Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.

Nakamura, Y., Ohto, Y., Murakami, A., Osawa, T., Ohigashi, H.

Jpn. J. Cancer Res., 89(4), 361-370 (1998).

12) Screening of edible plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.

Kim, O.K., Murakami, A., Nakamura, Y., Ohigashi, H.

Cancer Lett., 125(1-2), 199-207 (1998).

1997

11) Synthsis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H., Hayashi, H.

Biosci. Biotechnol. Biochem., 61(8), 1415-1417 (1997).

10) Cellular response to the redox active lipid peroxidation products: Induction of glutathione S-transferase P by 4-hydroxy-2-nonenal.

Fukuda, A., Nakamura, Y., Ohigashi, H., Osawa, T., Uchida, K.

Biochem. Biophys. Res. Commun., 236(2), 505-509 (1997).

9) Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin possibly through suppression of superoxide generation in leukocytes.

Murakami, A., Kuki, W., Takahashi, Y., Yonei, H., Nakamura, Y., Ohto, Y., Ohigashi, H., Koshimizu, K.

Jpn. J. Cancer Res., 88(5), 443-452 (1997).

1996

8) Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.

Nakamura, Y., Murakami, A., Koshimizu, K., Ohigashi, H.

Cancer Lett., 108(2), 247-255 (1996).

7) Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: Elucidation of the biologically active conformation of the tumor-promoting teleocidins.

Irie, K., Isaka, T., Iwata, Y., Yanai, Y., Nakamura, Y., Koizumi, F., Ohigashi, H., Wender, P.A., Satomi, Y., Nishino, H.

J. Am. Chem. Soc., 118(44), 10733-10743 (1996).

6) 1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.

Murakami, A., Ohura, S., Nakamura, Y., Koshimizu, K., Ohigashi, H.

Oncology, 53(5), 386-391 (1996).

5) Photocytotoxicity of water-soluble fullerene derivatives.

Irie, K., Nakamura, Y., Ohigashi, H., Tokuyama, H., Yamago, S., Nakamura, E.

Biosci. Biotechnol. Biochem., 60(8), 1359-1361 (1996).

4) Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea.

Nakamura, Y., Murakami, A., Koshimizu, K., Ohigashi, H.

Biosci. Biotechnol. Biochem., 60(6), 1028-1030 (1996).

1995

3) Glyceroglycolipids from Citrus hystrix, a traditional herb in Thailand, potently inhibit the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse skin.

Murakami, A., Nakamura, Y., Koshimizu, K., Ohigashi, H.

J. Agric. Food Chem., 43(10), 2779-2783 (1995).

2) Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins.

Irie, K., Koizumi, F., Iwata, Y., Ishii, T., Yanai, Y., Nakamura, Y., Ohigashi, H., Wender, P.A.

Bioorg. Med. Chem. Lett., 5(5), 453-458 (1995).

1993

1) Possible anti-tumor promoting properties of edible plants from Thailand, and identification of an active constituent, cardamonin, of Boesenbergia pandurata.

Murakami, A., Kondo, A., Nakamura, Y., Ohigashi, H., Koshimizu, K.

Biosci. Biotechnol. Biochem., 57(11), 1971-1973 (1993).